Abstract: Five antifungal drugs commonly used in the treatment of fungal eye diseases were tested against the common fungi associated with eye infections using standard agar disk diffusion method. All drugs examined except Floconazole (2%) showed high to moderate antifungal activity. All the 74 bacterial isolates tested against ten antibacterial drugs were affected by Cephotaxime, Ceftriaxone, Ciprofloxacin, Norfloxacin and Tetracycline. Most of drugs tested showed high to moderate effect on Gram-positive bacteria, and weak effect on Gram-negative bacteria, except Ciprofloxacin and Norfloxacin showed high or moderate effect against Pseudomonas aeruginosa. Treatment with proper antifungal and/or antibacterial agents will be of great advantage and ophthalmologists should be aware of the drug of choice to be used. Key words: Eye infection, drugs, Antibacterial, antifungal, fungi, bacteria.